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Is sex at birth a biological coin toss? Insights from a longitudinal and GWAS analysis

18 Jul 2025

Abstract excerpt

Some families consistently have offspring of only one sex, raising questions about whether sex at birth is truly random. This study investigated whether offspring sex follows a simple binomial distribution within families and identified maternal factors associated with unisexual sibships. We analyzed 58,007 US women with two or more singleton live births (146,064 pregnancies, 1956–2015). Offspring sex followed a...

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PMID: 40680119
DOI: 10.1126/sciadv.adu7402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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