Article
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device.
Nature biomedical engineering - 1 Jul 2021
Khodakov Dmitriy, Li Jiaming, Zhang Jinny X, Zhang David Yu
Abstract excerpt
Assays for the molecular detection of nucleic acids are typically constrained by the level of multiplexing (this is the case for the quantitative polymerase chain reaction (qPCR) and for isothermal amplification), turnaround times (as with microarrays and next-generation sequencing), quantification accuracy (isothermal amplification, microarrays and nanopore sequencing) or specificity for single-nucleotide...
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