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Article

Pathogenic and genetic landscape of Still's disease across ages, with new insights into age-related IL-18 patterns.

Arthritis research & therapy - 10 Apr 2026

Rogani Greta, Kessler Haeja, Mehta Bella, Baker Elizabeth, Leavis Helen, Vastert Sebastiaan, Schulert Grant

Abstract excerpt

Still's disease (SD) is now widely recognized as a single disease spectrum encompassing both childhood- and adult-onset forms. While most comparative studies so far have focused on clinical manifestations and treatment responses, aspects related to the pathophysiology of the disease including molecular mechanisms and genetic predisposition have remained less deeply explored.In this review, we provide an...

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PMID: 41964076
DOI: 10.1186/s13075-026-03808-8
PMCID: PMC13231706

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