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An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

3 Jun 2021

Abstract excerpt

Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses. The exogenous small interfering (si)RNA (exo-siRNA) pathway is believed to be the main antiviral defense in arthropods, including mosquitoes. During infection, double-stranded RNAs that form during viral replication and infection are cleaved by the enzyme...

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PMID: 34205194
DOI: 10.3390/v13061066

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