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Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense

28 Feb 2011

Abstract excerpt

BACKGROUND: Small RNA (sRNA) regulatory pathways (SRRPs) are important to anti-viral defence in mosquitoes. To identify critical features of the virus infection process in Dengue serotype 2 (DENV2)-infected Ae. aegypti, we deep-sequenced small non-coding RNAs. Triplicate biological replicates were used so that rigorous statistical metrics could be applied. RESULTS: In addition to virus-derived siRNAs (20-23 nts)...

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PMID: 21356105
DOI: 10.1186/1471-2180-11-45

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