Article
(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5.
International journal of molecular sciences - 15 Jun 2021
de Sousa Valente João, Alawi Khadija M, Bharde Sabah, Zarban Ali A, Kodji Xenia, Thapa Dibesh, Argunhan Fulye, Barrett Brentton, Nagy Istvan, Brain Susan D
Abstract excerpt
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis. (-)-Englerin A (EA), an extract from the East African plant Phyllanthus engleri has been identified as a TRPC4/5 agonist. Here, we studied whether or not EA has any anti-inflammatory and analgesic properties via TRPC4/5 in the carrageenan model of inflammation. We found that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.