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Article

Induction of Stress-Induced Renal Cellular Senescence In Vitro: Impact of Mouse Strain Genetic Diversity.

Cells - 8 Jun 2021

Liao Chieh Ming, Wulfmeyer Vera Christine, Swallow Maxine, Falk Christine Susanne, Haller Hermann, Korstanje Ron, Melk Anette, Schmitt Roland

Abstract excerpt

Cellular senescence, a stress-induced state of irreversible cell cycle arrest, is associated with organ dysfunction and age-related disease. While immortalized cell lines bypass key pathways of senescence, important mechanisms of cellular senescence can be studied in primary cells. Primary tubular epithelial cells (PTEC) derived from mouse kidney are highly susceptible to develop cellular senescence, providing a...

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PMID: 34201242
DOI: 10.3390/cells10061437
PMCID: PMC8229707

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