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Article

Use of Treatment-Focused Tumor Sequencing to Screen for Germline Cancer Predisposition.

The Journal of molecular diagnostics : JMD - 1 Sept 2021

Lau Tammy T Y, May Christina M, Sefid Dashti Zahra J, Swanson Lucas, Starks Elizabeth R, Parker Jeremy D K, Moore Richard A, Tucker Tracy, Bosdet Ian, Young Sean S, Santos Jennifer L, Compton Katie, Heidary Nili, Hoang Lien, Schrader Kasmintan A, Sun Sophie, Kwon Janice S, Tinker Anna V, Karsan Aly

Abstract excerpt

Next-generation sequencing assays are capable of identifying cancer patients eligible for targeted therapies and can also detect germline variants associated with increased cancer susceptibility. However, these capabilities have yet to be routinely harmonized in a single assay because of challenges with accurately identifying germline variants from tumor-only data. We have developed the Oncology and Hereditary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34197922
DOI: 10.1016/j.jmoldx.2021.06.006

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