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Article

Advanced maternal age perturbs mouse embryo development and alters the phenotype of derived embryonic stem cells.

Journal of developmental origins of health and disease - 1 Jun 2022

Khurana Pooja, Smyth Neil R, Sheth Bhavwanti, Velazquez Miguel A, Eckert Judith J, Fleming Tom P

Abstract excerpt

Advanced maternal age (AMA) is known to reduce fertility, increases aneuploidy in oocytes and early embryos and leads to adverse developmental consequences which may associate with offspring lifetime health risks. However, investigating underlying effects of AMA on embryo developmental potential is confounded by the inherent senescence present in maternal body systems further affecting reproductive success. Here,...

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PMID: 34193331
DOI: 10.1017/S2040174421000325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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