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Advanced paternal age directly impacts mouse embryonic placental imprinting

6 Mar 2020

Abstract excerpt

The placental epigenome plays a critical role in regulating mammalian growth and development. Alterations to placental methylation, often observed at imprinted genes, can lead to adverse pregnancy complications such as intrauterine growth restriction and preterm birth. Similar associations have been observed in offspring derived from advanced paternal age fathers. As parental age at time of conception continues...

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Share to Epigenetics and DNA Methylation
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PMID: 32142542
DOI: 10.1371/journal.pone.0229904

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