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Article

Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia.

Scientific reports - 29 Jun 2021

Minyaylo Oksana, Ponomarenko Irina, Reshetnikov Evgeny, Dvornyk Volodymyr, Churnosov Mikhail

Abstract excerpt

This study analyzed the association of functionally significant SNPs of matrix metalloproteinase (MMP) genes in the development of peptic ulcer disease (PUD) in Caucasians from Central Russia. Ten SNPs of the MMP-1, MMP-2, MMP-3, MMP-8, and MMP-9 genes were analyzed for association with PUD in a cohort of 798 patients with PUD (including 404 H. pylori-positive and 394 H. pylori-negative) and 347 H....

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Identifiers

PMID: 34188075
DOI: 10.1038/s41598-021-92527-y
PMCID: PMC8241834

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