Article
Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.
mBio - 29 Jun 2021
Campbell Christopher, Fingleton Claire, Zeden Merve S, Bueno Emilio, Gallagher Laura A, Shinde Dhananjay, Ahn Jongsam, Olson Heather M, Fillmore Thomas L, Adkins Joshua N, Razvi Fareha, Bayles Kenneth W, Fey Paul D, Thomas Vinai C, Cava Felipe, Clair Geremy C, O'Gara James P
Abstract excerpt
Penicillin binding protein 2a (PBP2a)-dependent resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the tricarboxylic acid (TCA) cycle via a poorly understood mechanism. We report that mutations in sucC and sucD, but not other TCA cycle enzymes, negatively impact β-lactam resistance without changing PBP2a expression. Increased intracellular...
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