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Article

Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ.

The Journal of allergy and clinical immunology - 1 Jan 2022

Tsumura Miyuki, Miki Mizuka, Mizoguchi Yoko, Hirata Osamu, Nishimura Shiho, Tamaura Moe, Kagawa Reiko, Hayakawa Seiichi, Kobayashi Masao, Okada Satoshi

Abstract excerpt

BACKGROUND: Patients with Mendelian susceptibility to mycobacterial disease (MSMD) experience recurrent and/or persistent infectious diseases associated with poorly virulent mycobacteria. Multifocal osteomyelitis is among the representative manifestations of MSMD. The frequency of multifocal osteomyelitis is especially high in patients with MSMD etiologies that impair cellular response to IFN-γ, such as IFN-γR1,...

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Identifiers

PMID: 34176646
DOI: 10.1016/j.jaci.2021.05.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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