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Article

Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective.

Biological psychiatry - 15 Sept 2021

De Los Angeles Alejandro, Fernando Michael B, Hall Nicola A L, Brennand Kristen J, Harrison Paul J, Maher Brady J, Weinberger Daniel R, Tunbridge Elizabeth M

Abstract excerpt

A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging capacity to derive neural cells and circuits from human induced pluripotent stem cells (iPSCs) has generated significant excitement. This review aims to provide a critical appraisal of the...

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Identifiers

PMID: 34176589
DOI: 10.1016/j.biopsych.2021.04.008
PMCID: PMC8375580

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