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Article

DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity.

Cellular and molecular life sciences : CMLS - 1 Aug 2021

Kok Jannigje Rachel, Palminha Nelma M, Dos Santos Souza Cleide, El-Khamisy Sherif F, Ferraiuolo Laura

Abstract excerpt

Increasing evidence supports the involvement of DNA damage in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Elevated levels of DNA damage are consistently observed in both sporadic and familial forms of ALS and may also play a role in Western Pacific ALS, which is thought to have an environmental cause. The cause of DNA damage in ALS remains unclear but likely differs between...

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Identifiers

PMID: 34173837
DOI: 10.1007/s00018-021-03872-0
PMCID: PMC8316199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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