Article
Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study.
The European respiratory journal - 1 Feb 2022
Nakanishi Tomoko, Cerani Agustin, Forgetta Vincenzo, Zhou Sirui, Allen Richard J, Leavy Olivia C, Koido Masaru, Assayag Deborah, Jenkins R Gisli, Wain Louise V, Yang Ivana V, Lathrop G Mark, Wolters Paul J, Schwartz David A, Richards J Brent
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal fibrotic interstitial lung disease. Few circulating biomarkers have been identified to have causal effects on IPF. METHODS: To identify candidate IPF-influencing circulating proteins, we undertook an efficient screen of circulating proteins by applying a two-sample Mendelian randomisation (MR) approach with existing publicly available data....
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