Article
Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies.
NeuroImage. Clinical - 1 Jan 2021
Mortazavi Matin, Hizarci Öznur, Gerdes Lisa Ann, Havla Joachim, Kümpfel Tania, Hohlfeld Reinhard, Stöcklein Sophia, Keeser Daniel, Ertl-Wagner Birgit
Abstract excerpt
Multiple genetic and non-heritable factors have been linked to the risk of multiple sclerosis (MS). These factors seem to contribute to disease pathogenesis before the onset of clinical symptoms, as suggested by incidental MRI evidence of subclinical MS neuropathology in individuals without clinical symptoms. Individuals with high familial risk for MS, such as first-degree relatives of patients with MS, can be...
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