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Article

High Purity Isolation of Low Density Neutrophils Casts Doubt on Their Exceptionality in Health and Disease.

Frontiers in immunology - 1 Jan 2021

Hardisty Gareth R, Llanwarne Frances, Minns Danielle, Gillan Jonathan L, Davidson Donald J, Gwyer Findlay Emily, Gray Robert D

Abstract excerpt

Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers and infections and associated with immunopathology, and a mechanistic role in disease. The role of LDNs at homeostasis in healthy individuals has not been investigated. We have developed an isolation protocol that generates high purity LDNs from healthy donors. Healthy LDNs were identical to healthy normal density...

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Identifiers

PMID: 34168640
DOI: 10.3389/fimmu.2021.625922
PMCID: PMC8217868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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