Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of the gene mosaicism burden in blood and its implications for immune disorders.

Scientific reports - 21 Jun 2021

Solís-Moruno Manuel, Mensa-Vilaró Anna, Batlle-Masó Laura, Lobón Irene, Bonet Núria, Marquès-Bonet Tomàs, Aróstegui Juan I, Casals Ferran

Abstract excerpt

There are increasing evidences showing the contribution of somatic genetic variants to non-cancer diseases. However, their detection using massive parallel sequencing methods still has important limitations. In addition, the relative importance and dynamics of somatic variation in healthy tissues are not fully understood. We performed high-depth whole-exome sequencing in 16 samples from patients with a previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Genomics

Share to Immune System Diseases

Share to Mosaicism

Share to Organ Specificity

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 34155260
DOI: 10.1038/s41598-021-92381-y
PMCID: PMC8217568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of the gene mosaicism burden in blood and its implications for immune disorders.PMID 34155260Read ↗

Somatic Variants: New Kids on the Block in Human Immunogenetics.Semantic proximity Read ↗

The genetic determinants of recurrent somatic mutations in 43,693 blood genomes.Semantic proximity Read ↗

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read ↗

Next-Generation Sequencing in the Field of Primary Immunodeficiencies: Current Yield, Challenges, and Future PerspectivesSemantic proximity Read ↗

Driving mosaicism: somatic variants in reference population databases and effect on variant interpretation in rare genetic disease.Semantic proximity Read ↗

Somatic mutations in autoinflammatory and autoimmune disease.Semantic proximity Read ↗

The Utility of Next-Generation Sequencing for Primary Immunodeficiency Disorders: Experience from a Clinical Diagnostic LaboratorySemantic proximity Read ↗

Contribution of high‐throughput DNA sequencing to the study of primary immunodeficienciesSemantic proximity Read ↗

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.Semantic proximity Read ↗

Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgroundsSemantic proximity Read ↗

Genetic Mosaicism as a Cause of Inborn Errors of Immunity.Semantic proximity Read ↗

Somatic genetic variation in healthy tissue and non-cancer diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.