Article
Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN - 1 Oct 2021
Lu Yueh-An, Liao Chia-Te, Raybould Rachel, Talabani Bnar, Grigorieva Irina, Szomolay Barbara, Bowen Timothy, Andrews Robert, Taylor Philip R, Fraser Donald
Abstract excerpt
BACKGROUND: Proximal tubular cells (PTCs) are the most abundant cell type in the kidney. PTCs are central to normal kidney function and to regeneration versus organ fibrosis following injury. This study used single-nucleus RNA sequencing (snRNAseq) to describe the phenotype of PTCs in renal fibrosis. METHODS: Kidneys were harvested from naïve mice and from mice with renal fibrosis induced by chronic aristolochic...
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