Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy.

doi:10.1016/j.urology.2021.05.055

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Article

Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy.

Urology - 1 Nov 2021

Tully Karl H, Jütte Hendrik, Wirtz Ralph M, Jarczyk Jonas, Santiago-Walker Ademi, Zengerling Friedemann, Breyer Johannes, Sikic Danijel, Kriegmair Maximilian C, von Hardenberg Jost, Wullich Bernd, Taubert Helge, Weyerer Veronika, Stoehr Robert, Bolenz Christian, Burger Maximilian, Porubsky Stefan, Hartmann Arndt, Roghmann Florian, Erben Philipp, Eckstein Markus

Abstract excerpt

OBJECTIVE: To examine the disease-specific survival(DSS) after checkpoint inhibitor(CPI) therapy based on FGFR alterations and FGFR mRNA expression levels in patients with metastatic urothelial cancer(mUCa) within a multi-center cohort. METHODS: Within a cohort of 72 patients with mUCa from five academic centers in Germany FGFR alterations, as well as FGFR1-4 mRNA expression levels in tumor samples from the...

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PMID: 34153367
DOI: 10.1016/j.urology.2021.05.055

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