Article

SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

2025-08-28

Abstract excerpt

<h4>SUMMARY</h4> Tens of thousands of severe COVID-19 cases are hospitalized weekly in the U.S., often driven by an imbalance between antiviral responses and inflammatory signaling, leading to uncontrolled cytokine secretion. The SARS-CoV-2 nucleocapsid (N) protein is a known immune antagonist, but its role in macrophage-driven cytokine storms is unclear. We demonstrate that N functions in a pathway-specific mann...

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Literature Corpus work: 93981da7-7ca5-50c8-b606-ed8634aabff0
DOI: 10.1101/2025.08.28.672752

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