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Article

A genetic polymorphism in P2RY1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy.

Scientific reports - 15 Jun 2021

Ueda Yu, Li Ronald H L, Nguyen Nghi, Ontiveros Eric S, Kovacs Samantha L, Oldach Maureen S, Vernau Karen M, Court Michael H, Stern Joshua A

Abstract excerpt

Clopidogrel is converted to its active metabolite by cytochrome P450 isoenzymes and irreversibly inhibits platelet activation by antagonizing the adenosine-diphosphate (ADP) receptor. It is frequently used in cats with hypertrophic cardiomyopathy (HCM) to prevent thromboembolic complications. However, significant interpatient variability of the response to clopidogrel therapy has been suspected. In this study, we...

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Identifiers

PMID: 34131167
DOI: 10.1038/s41598-021-91372-3
PMCID: PMC8206363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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