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AI-guided discovery of the invariant host response to viral pandemics

1 Jun 2021

Abstract excerpt

BACKGROUND: Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach. METHOD: Over 45,000 transcriptomic datasets of viral pandemics were analyzed to extract a 166-gene signature using ACE2 as a 'seed' gene;...

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PMID: 34127431
DOI: 10.1016/j.ebiom.2021.103390

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