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Utilizing single-cell RNA sequencing for analyzing the characteristics of PBMC in patients with Kawasaki disease

14 Jun 2021

Abstract excerpt

BACKGROUND: Kawasaki disease (KD) is the main cause of acquired heart disease in children and can lead to coronary artery lesions. This present study was designed to analyze the characteristics of KD peripheral blood mononuclear cells (PBMC) through single-cell RNA sequencing (scRNA-seq) and to explore the potential molecular mechanism of KD. METHODS: PBMC was collected from one healthy child and one KD patient,...

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PMID: 34126969
DOI: 10.1186/s12887-021-02754-5

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