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Identification of novel metabolism-related biomarkers of Kawasaki disease by integrating single-cell RNA sequencing analysis and machine learning algorithms

10 Apr 2025

Abstract excerpt

Background: The bile acid metabolism (BAM) and fatty acid metabolism (FAM) have been implicated in Kawasaki disease (KD), but their precise mechanisms remain unclear. Identifying signature cells and genes related to BAM and FAM could offer a deeper understanding of their role in the pathogenesis of KD. Method: We analyzed the public single-cell RNA sequencing (scRNA-seq) dataset GSE1687323 to characterize the...

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PMID: 40276515
DOI: 10.3389/fimmu.2025.1541939

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