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Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans

14 Jun 2021

Abstract excerpt

Dietary sodium affects blood pressure (BP) and vascular function. Animal studies suggest epigenetic changes (eg, DNA methylation) are involved. We hypothesized that sodium restriction induces methylation changes in T cells and arterioles in humans. Fifty subjects (49% women) were placed on 1200-mg sodium/day diet for 2 weeks. BP and brachial artery flow-mediated dilation were evaluated. Methylation sequencing...

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PMID: 34120454
DOI: 10.1161/hypertensionaha.120.17351

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