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Article

Sodium Reduction, miRNA Profiling and CVD Risk in Untreated Hypertensives: a Randomized, Double-Blind, Placebo-Controlled Trial.

Scientific reports - 24 Aug 2018

Chen Li, He Feng J, Dong Yanbin, Huang Ying, Harshfield Gregory A, Zhu Haidong

Abstract excerpt

Sodium reduction decreases blood pressure (BP) and cardiovascular mortality. However, the underlying molecular mechanisms are not well understood. We tested the hypothesis that reduction of sodium intake would change miRNA expression in hypertensive patients, and those changes would be associated with improved cardiovascular phenotypes. A whole genome RNA sequencing was performed in paired serum samples collected...

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Identifiers

PMID: 30143705
DOI: 10.1038/s41598-018-31139-5
PMCID: PMC6109065

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