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Article

Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension

10 Oct 2018

Abstract excerpt

Numerous adult diseases involving tissues consisting primarily of nondividing cells are associated with changes in DNA methylation. It suggests a pathophysiological role for de novo methylation or demethylation of DNA, which is catalyzed by DNA methyltransferase 3 and ten-eleven translocases. However, the contribution of DNA de novo (de)methylation to these diseases remains almost completely unproven. Broad...

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PMID: 30354815
DOI: 10.1161/hypertensionaha.118.11650

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