Article
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.
American journal of human genetics - 1 Jul 2021
Kosmicki Jack A, Horowitz Julie E, Banerjee Nilanjana, Lanche Rouel, Marcketta Anthony, Maxwell Evan, Bai Xiaodong, Sun Dylan, Backman Joshua D, Sharma Deepika, Kury Fabricio S P, Kang Hyun M, O'Dushlaine Colm, Yadav Ashish, Mansfield Adam J, Li Alexander H, Watanabe Kyoko, Gurski Lauren, McCarthy Shane E, Locke Adam E, Khalid Shareef, O'Keeffe Sean, Mbatchou Joelle, Chazara Olympe, Huang Yunfeng, Kvikstad Erika, O'Neill Amanda, Nioi Paul, Parker Meg M, Petrovski Slavé, Runz Heiko, Szustakowski Joseph D, Wang Quanli, Wong Emily, Cordova-Palomera Aldo, Smith Erin N, Szalma Sandor, Zheng Xiuwen, Esmaeeli Sahar, Davis Justin W, Lai Yi-Pin, Chen Xing, Justice Anne E, Leader Joseph B, Mirshahi Tooraj, Carey David J, Verma Anurag, Sirugo Giorgio, Ritchie Marylyn D, Rader Daniel J, Povysil Gundula, Goldstein David B, Kiryluk Krzysztof, Pairo-Castineira Erola, Rawlik Konrad, Pasko Dorota, Walker Susan, Meynert Alison, Kousathanas Athanasios, Moutsianas Loukas, Tenesa Albert, Caulfield Mark, Scott Richard, Wilson James F, Baillie J Kenneth, Butler-Laporte Guillaume, Nakanishi Tomoko, Lathrop Mark, Richards J Brent, Jones Marcus, Balasubramanian Suganthi, Salerno William, Shuldiner Alan R, Marchini Jonathan, Overton John D, Habegger Lukas, Cantor Michael N, Reid Jeffrey G, Baras Aris, Abecasis Goncalo R, Ferreira Manuel A R
Abstract excerpt
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear...
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