Survival of chemo-naïve patients with EGFR mutation-positive advanced non-small cell lung cancer after treatment with afatinib and bevacizumab: updates from the Okayama Lung Cancer Study Group Trial 1404.

doi:10.1093/jjco/hyab084

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Survival of chemo-naïve patients with EGFR mutation-positive advanced non-small cell lung cancer after treatment with afatinib and bevacizumab: updates from the Okayama Lung Cancer Study Group Trial 1404.

Japanese journal of clinical oncology - 1 Aug 2021

Ninomiya Takashi, Nogami Naoyuki, Kozuki Toshiyuki, Harada Daijiro, Kubo Toshio, Ohashi Kadoaki, Ichihara Eiki, Kuyama Shoichi, Kudo Kenichiro, Bessho Akihiro, Sakugawa Makoto, Fujimoto Nobukazu, Aoe Keisuke, Minami Daisuke, Sugimoto Keisuke, Ochi Nobuaki, Takigawa Nagio, Hotta Katsuyuki, Maeda Yoshinobu, Kiura Katsuyuki

Abstract excerpt

BACKGROUND: In a phase I study, afatinib (30 mg/body daily) plus bevacizumab (15 mg/kg every 3 weeks) was well tolerated and showed favourable outcomes in patients with epidermal growth factor receptor (EGFR)-mutant advanced non-small-cell lung cancer. Herein, we report the 2-year progression-free survival, overall survival and safety profile of these patients. METHODS: Chemo-naïve patients with EGFR-mutant...

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PMID: 34115855
DOI: 10.1093/jjco/hyab084

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