First-Line Afatinib plus Cetuximab for EGFR-Mutant Non-Small Cell Lung Cancer: Results from the Randomized Phase II IFCT-1503 ACE-Lung Study.

doi:10.1158/1078-0432.CCR-20-4604

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Article

First-Line Afatinib plus Cetuximab for EGFR-Mutant Non-Small Cell Lung Cancer: Results from the Randomized Phase II IFCT-1503 ACE-Lung Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2021

Cortot Alexis B, Madroszyk Anne, Giroux-Leprieur Etienne, Molinier Olivier, Quoix Elisabeth, Bérard Henri, Otto Josiane, Rault Isabelle, Moro-Sibilot Denis, Raimbourg Judith, Amour Elodie, Morin Franck, Hureaux José, Moreau Lionel, Debieuvre Didier, Morel Hugues, Renault Aldo, Pichon Eric, Huret Benjamin, Charpentier Sandrine, Denis Marc G, Cadranel Jacques

Abstract excerpt

PURPOSE: Double inhibition of epidermal growth factor receptor (EGFR) using a tyrosine kinase inhibitor plus a monoclonal antibody may be a novel treatment strategy for non-small cell lung cancer (NSCLC). We assessed the efficacy and toxicity of afatinib + cetuximab versus afatinib alone in the first-line treatment of advanced EGFR-mutant NSCLC. PATIENTS AND METHODS: In this phase II, randomized, open-label...

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PMID: 34031056
DOI: 10.1158/1078-0432.CCR-20-4604

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