Article
A phase I trial of afatinib and bevacizumab in chemo-naïve patients with advanced non-small-cell lung cancer harboring EGFR mutations: Okayama Lung Cancer Study Group Trial 1404.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2018
Ninomiya Takashi, Nogami Naoyuki, Kozuki Toshiyuki, Harada Daijiro, Kubo Toshio, Ohashi Kadoaki, Kuyama Shoichi, Kudo Kenichiro, Bessho Akihiro, Fukamatsu Nobuaki, Fujimoto Nobukazu, Aoe Keisuke, Shibayama Takuo, Sugimoto Keisuke, Takigawa Nagio, Hotta Katsuyuki, Kiura Katsuyuki
Abstract excerpt
OBJECTIVE: In advanced epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC), treatment with afatinib, a second-generation EGFR-tyrosine kinase inhibitor (TKI), confers a significant survival benefit over platinum-based chemotherapy. The first-generation EGFR-TKIs gefitinib and erlotinib in combination with bevacizumab have improved progression-free survival. We hypothesized that the...
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