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A randomized phase II study of afatinib alone or combined with bevacizumab for treating chemo-naïve patients with non-small cell lung cancer harboring EGFR mutations.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2023

Ninomiya Takashi, Ishikawa Nobuhisa, Kozuki Toshiyuki, Kuyama Shoichi, Inoue Koji, Yokoyama Toshihide, Kanaji Nobuhiro, Yasugi Masayuki, Shibayama Takuo, Aoe Keisuke, Ochi Nobuaki, Fujitaka Kazunori, Kodani Masahiro, Ueda Yutaka, Watanabe Kazuhiko, Bessho Akihiro, Sugimoto Keisuke, Oze Isao, Hotta Katsuyuki, Kiura Katsuyuki

Abstract excerpt

BACKGROUND: Adding bevacizumab to first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) prolonged the progression-free survival (PFS), but limited data are available for second-generation EGFR-TKIs. AfaBev-CS is a randomized, phase II trial comparing afatinib plus bevacizumab and afatinib alone as first-line treatment. PATIENTS AND METHODS: Untreated patients with non-squamous...

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PMID: 37651927
DOI: 10.1016/j.lungcan.2023.107349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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