Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.

doi:10.1038/tpj.2010.92

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Article

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.

The pharmacogenomics journal - 1 Jun 2012

Brunham L R, Lansberg P J, Zhang L, Miao F, Carter C, Hovingh G K, Visscher H, Jukema J W, Stalenhoef A F, Ross C J D, Carleton B C, Kastelein J J P, Hayden M R

Abstract excerpt

Statins reduce cardiovascular morbidity and mortality in appropriately selected patients. However, statin-associated myopathy is a significant risk associated with these agents. Recently, variation in the SLCO1B1 gene was reported to predict simvastatin-associated myopathy. The aim of this study was to replicate association of the rs4149056 variant in SLCO1B1 with severe statin-associated myopathy in a cohort of...

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PMID: 21243006
DOI: 10.1038/tpj.2010.92

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