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Article

Structural and numerical Y chromosomal variations in elderly men identified through multiplex ligation-dependent probe amplification.

Journal of human genetics - 1 Dec 2021

Ogiwara Yasuko, Miyado Mami, Suzuki Erina, Niida Sumpei, Ozaki Kouichi, Fukami Maki

Abstract excerpt

Human Y chromosomes frequently acquire structural and numerical alterations. Known alterations include germline copy-number variations (CNVs) in the azoospermia factor (AZF) region and somatic mosaic loss of the Y chromosome (mLOY). Here, we explored Y chromosomal variations in 160 Japanese men aged 75-90 years. Multiplex ligation-dependent probe amplification (MLPA) identified ten types of AZF-linked CNVs in 77...

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PMID: 34108640
DOI: 10.1038/s10038-021-00943-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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