Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.

Scientific reports - 9 Jun 2021

Chen Chen, Gao Dan, Huo Jinlong, Qu Rui, Guo Youming, Hu Xiaochi, Luo Libo

Abstract excerpt

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer (BrC) subtype lacking effective therapeutic targets currently. The development of multi-omics databases facilities the identification of core genes for TNBC. Using TCGA-BRCA and METABRIC datasets, we identified CT83 as the most TNBC-specific gene. By further integrating FUSCC-TNBC, CCLE, TCGA pan-cancer, Expression Atlas, and Human Protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to DNA Copy Number Variations

Share to Proteome

Share to Survival Rate

Share to Triple Negative Breast Neoplasms

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 34108519
DOI: 10.1038/s41598-021-91290-4
PMCID: PMC8190062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.PMID 34108519Read ↗

Highly heterogeneous-related genes of triple-negative breast cancer: potential diagnostic and prognostic biomarkersSemantic proximity Read ↗

ABCC9, NKAPL, and TMEM132C are potential diagnostic and prognostic markers in triple‐negative breast cancerSemantic proximity Read ↗

Molecular Classification and Future Therapeutic Challenges of Triple-negative Breast CancerSemantic proximity Read ↗

An insight into the development of triple-negative breast cancer at transcriptome level based on single-cell sequencing technologySemantic proximity Read ↗

Analysis of gene expression profiles to elucidate racial differences in African American and White patients with Triple-negative breast cancerSemantic proximity Read ↗

Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast CancerSemantic proximity Read ↗

Tumor Mutation Burden and Immune Invasion Characteristics in Triple Negative Breast Cancer: Genome High-Throughput Data Analysis.Semantic proximity Read ↗

Prognostic significance of FAM83D gene expression across human cancer types.Semantic proximity Read ↗

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screenSemantic proximity Read ↗

Overexpression of PKMYT1 associated with poor prognosis and immune infiltration may serve as a target in triple-negative breast cancerSemantic proximity Read ↗

Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancerSemantic proximity Read ↗

Microarray expression profiling of dysregulated long non-coding RNAs in triple-negative breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.