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Article

Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer

7 Nov 2017

Abstract excerpt

BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by a lack of estrogen and progesterone receptor expression (ESR and PGR, respectively) and an absence of human epithelial growth factor receptor (ERBB2) amplification. Approximately 15-20% of breast malignancies are TNBC. Patients with TNBC often have an unfavorable prognosis. In addition, TNBC represents an important clinical challenge since it...

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PMID: 29115931
DOI: 10.1186/s12885-017-3726-2

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