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Article

Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients.

Scientific reports - 9 Jun 2021

Naseem Madiha, Cao Shu, Yang Dongyun, Millstein Joshua, Puccini Alberto, Loupakis Fotios, Stintzing Sebastian, Cremolini Chiara, Tokunaga Ryuma, Battaglin Francesca, Soni Shivani, Berger Martin D, Barzi Afsaneh, Zhang Wu, Falcone Alfredo, Heinemann Volker, Lenz Heinz-Josef

Abstract excerpt

KRAS status serves as a predictive biomarker of response to treatment in metastatic colorectal cancer (mCRC). We hypothesize that complex interactions between multiple pathways contribute to prognostic differences between KRAS wild-type and KRAS mutant patients with mCRC, and aim to identify polymorphisms predictive of clinical outcomes in this subpopulation. Most pathway association studies are limited in...

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Identifiers

PMID: 34108518
DOI: 10.1038/s41598-021-91330-z
PMCID: PMC8190302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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