Article
Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System.
Applied and environmental microbiology - 27 Jul 2021
Kunttu Heidi M T, Runtuvuori-Salmela Anniina, Sundell Krister, Wiklund Tom, Middelboe Mathias, Landor Lotta, Ashrafi Roghaieh, Hoikkala Ville, Sundberg Lotta-Riina
Abstract excerpt
Increasing problems with antibiotic resistance have directed interest toward phage therapy in the aquaculture industry. However, phage resistance evolving in target bacteria is considered a challenge. To investigate how phage resistance influences the fish pathogen Flavobacterium columnare, two wild-type bacterial isolates, FCO-F2 and FCO-F9, were exposed to phages (FCO-F2 to FCOV-F2, FCOV-F5, and FCOV-F25, and...
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