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Article

Development of a method for the determination of the JAK2 gene mRNA in venous blood and assessment of its diagnostic value in oncohematology.

Klinicheskaia laboratornaia diagnostika - 7 Jun 2021

Stolyar M A, Gorbenko A S, Olkhovskiy I A, Bakhtina V I, Mikhalev M A, Olkhovik T I, Komarovskiy Yu Yu

Abstract excerpt

Overactive JAK pathway signaling is a hallmark of immune diseases and critically affects on inflammation and coagulation. A number of mutations in the JAK2 gene act as driving forces of myeloproliferative neoplasms (MPN), the pathogenesis of certain variants of acute leukemia, a number of solid malignancies and cardiovascular diseases. Assays for quantifying JAK2 mRNA in circulating blood cells can be used as a...

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PMID: 34105916
DOI: 10.51620/0869-2084-2021-66-6-379-384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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