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Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts

9 Jun 2021

Abstract excerpt

Advanced maternal age (AMA) pregnancy is associated with higher risks of adverse perinatal outcomes, which may result from premature senescence of the placenta. α-Klotho is a well-known antiaging protein; however, its expression and effect on the placenta in AMA pregnancies have not yet been fully elucidated. The expression patterns of α-Klotho in mouse and human placentas from AMA pregnancies were determined by...

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PMID: 34105233
DOI: 10.1111/acel.13417

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