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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP

21 Jan 2025

Abstract excerpt

Introduction The advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast aging in AMA placenta remain unclear, posing a significant limitation to...

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PMID: 39906872
DOI: 10.3389/fcell.2025.1479960

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