Article
Plasma Mucin-1 (CA15-3) Levels in Autosomal Dominant Tubulointerstitial Kidney Disease due to MUC1 Mutations.
American journal of nephrology - 1 Jan 2021
Vylet'al Petr, Kidd Kendrah, Ainsworth Hannah C, Springer Drahomíra, Vrbacká Alena, Přistoupilová Anna, Hughey Rebecca P, Alper Seth L, Lennon Niall, Harrison Steven, Harden Maegan, Robins Victoria, Taylor Abbigail, Martin Lauren, Howard Katrice, Bitar Ibrahim, Langefeld Carl D, Barešová Veronika, Hartmannová Hana, Hodaňová Kateřina, Zima Tomáš, Živná Martina, Kmoch Stanislav, Bleyer Anthony J
Abstract excerpt
INTRODUCTION: Patients with ADTKD-MUC1 have one allele producing normal mucin-1 (MUC1) and one allele producing mutant MUC1, which remains intracellular. We hypothesized that ADTKD-MUC1 patients, who have only 1 secretory-competent wild-type MUC1 allele, should exhibit decreased plasma mucin-1 (MUC1) levels. To test this hypothesis, we repurposed the serum CA15-3 assay used to measure MUC1 in breast cancer to...
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