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Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL

21 May 2021

Abstract excerpt

We and others have reported that Notch3 is a regulator of adult hippocampal neurogenesis. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), the most common genetic form of vascular dementia, is caused by mutations in Notch3 . The present study intended to investigate whether there is a correlation between altered adult hippocampal neurogenesis and spatial memory...

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PMID: 34093162
DOI: 10.3389/fnagi.2021.617733

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Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASILPMID 34093162Read ↗

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