Article
Generation of a human induced pluripotent stem cell (iPSC) line (IBMS-iPSC-048-05) from a patient with ALS and parkinsonism having a hexanucleotide repeat expansion mutation in C9orf72 gene.
Stem cell research - 1 Apr 2020
Lin Han-Yi, Tsai Li-Kai, Cheng Yu-Che, Lu Huai-En, Huang Ching-Ying, Hsieh Patrick C H, Lin Chin-Hsien
Abstract excerpt
A hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) gene causes a heterogeneous neurodegenerative disorder that includes amyotrophic lateral sclerosis (ALS), frontotemporal degeneration (FTD), and parkinsonism. Here, we used the Sendai virus delivery system to generate induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells of a male patient with an increased...
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