Article
Diversity and population structure of Plasmodium falciparum in Thailand based on the spatial and temporal haplotype patterns of the C-terminal 19-kDa domain of merozoite surface protein-1.
Malaria journal - 12 Feb 2014
Simpalipan Phumin, Pattaradilokrat Sittiporn, Siripoon Napaporn, Seugorn Aree, Kaewthamasorn Morakot, Butcher Robert D J, Harnyuttanakorn Pongchai
Abstract excerpt
BACKGROUND: The 19-kDa C-terminal region of the merozoite surface protein-1 of the human malaria parasite Plasmodium falciparum (PfMSP-119) constitutes the major component on the surface of merozoites and is considered as one of the leading candidates for asexual blood stage vaccines. Because the protein exhibits a level of sequence variation that may compromise the effectiveness of a vaccine, the global sequence...
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