Article
Prediction of Type 1 Diabetes at Birth: Cord Blood Metabolites vs Genetic Risk Score in the Norwegian Mother, Father, and Child Cohort.
The Journal of clinical endocrinology and metabolism - 27 Sept 2021
Tapia German, Suvitaival Tommi, Ahonen Linda, Lund-Blix Nicolai A, Njølstad Pål R, Joner Geir, Skrivarhaug Torild, Legido-Quigley Cristina, Størdal Ketil, Stene Lars C
Abstract excerpt
BACKGROUND AND AIM: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We studied whether selected polar metabolites in cord blood contribute to prediction of type 1 diabetes. METHODS: Using a targeted UHPLC-QQQ-MS platform, we quantified 27 low-molecular-weight...
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