Article
Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Wasserman Danit, Nachum Sapir, Noach-Hirsh Meirav, Auerbach Naomi, Sheinberger-Chorni Evelin, Enrico Taylor P, Lahmi Roxane, Emanuele Michael J, Tzur Amit
Abstract excerpt
A balanced progression through mitosis and cell division is largely dependent on orderly phosphorylation and ubiquitin-mediated proteolysis of regulatory and structural proteins. These series of events ultimately secure genome stability and time-invariant cellular properties during cell proliferation. Two of the core enzymes regulating mitotic milestones in all eukaryotes are cyclin dependent kinase 1 (CDK1) with...
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