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Article

Osmotic stress and vesiculation as key mechanisms controlling bacterial sensitivity and resistance to TiO2 nanoparticles.

Communications biology - 3 Jun 2021

Pagnout Christophe, Razafitianamaharavo Angelina, Sohm Bénédicte, Caillet Céline, Beaussart Audrey, Delatour Eva, Bihannic Isabelle, Offroy Marc, Duval Jérôme F L

Abstract excerpt

Toxicity mechanisms of metal oxide nanoparticles towards bacteria and underlying roles of membrane composition are still debated. Herein, the response of lipopolysaccharide-truncated Escherichia coli K12 mutants to TiO2 nanoparticles (TiO2NPs, exposure in dark) is addressed at the molecular, single cell, and population levels by transcriptomics, fluorescence assays, cell nanomechanics and electrohydrodynamics. We...

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Identifiers

PMID: 34083706
DOI: 10.1038/s42003-021-02213-y
PMCID: PMC8175758

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